High dose zoledronic acid increases ischemia-reperfusion damage of the liver
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.25, no.9, pp.3567-3575, 2021 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 25 Issue: 9
- Publication Date: 2021
- Doi Number: 10.26355/eurrev_202105_25839
- Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Page Numbers: pp.3567-3575
- Keywords: Zoledronic acid, Ischemia-reperfusion injury, Liver, Caspase, KUPFFER CELLS, INJURY, KIDNEY, METASTASIS, APOPTOSIS, PROTEIN, CANCER
- Ondokuz Mayıs University Affiliated: No
Abstract
OBJECTIVE: Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, has been reported to exhibit a protective effect against cancers and prevent bone fractures. It also induces apoptosis by increasing proinflammatory cytokines and oxidative stress. Oxidative stress increases significantly during ischemia-reperfusion (IR) injury. The liver is highly sensitive to IR injury. In this study, we aim to investigate whether high-dose ZA treatment affects the liver during IR.