The sustainable development of enterprises, industries, and complexes in the conditions of formation of the digital economy in industrialized regions must be based on the principles of the ESG agenda with an important factor to control the impact of industrial production on the environmental component of the regional space in terms of the intensification of production carried out in the implementation of import substitution. The paper examines the dynamics of the relationship between the industrial production index and a set of indicators characterizing the ecological state of the regional space. The selected set of indicators, revealing the level of anthropogenic load on the environment of the region, is aggregated into an integrated index of the regional environmental profile. Based on the trend model of the relationship between the industrial production index and the integrated index of the ecological regional profile through the example of one of the industrial centers of the Russian Federation—the Perm Territory—the paper substantiates the tendency of industrial development of the region toward sustainability in the form of coexistence of interrelated trends of industrial growth and the relative stability of indicators of the regional environmental profile. For the Perm Territory, the relationship of the studied indicators is inverse, which is expressed in the presence of the decoupling effect and confirms the introduction of digital and innovative technologies is a prerequisite for the sustainable economic development of industrially-oriented regions in the digital space.