Effect of intranasal midazolam - butorphanol premedication on sevoflurane anaesthesia intraumatized buzzards (Buteo spp.)


Nacar C., Nisbet H. Ö.

7th International Conference on Avian, Herpetological, Exotic Mammal, Zoo and Wildlife Medicine, Lisbon, Portekiz, 11 - 15 Nisan 2026, ss.198, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Lisbon
  • Basıldığı Ülke: Portekiz
  • Sayfa Sayıları: ss.198
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Introduction: This study aimed to investigate the effects of intranasal midazolam-butorphanol combination on premedication, sevoflurane anaesthesia, and recovery phases in common buzzards (Buteo buteo). Patients and Methods: Sixteen buzzards requiring surgery due to orthopaedic trauma were randomly assigned to two groups. To ensure pre-emptive analgesia, meloxicam (0.5mg/kg PO) was administered to all buzzards prior to anaesthetic induction. The experimental group received intranasal midazolam (2mg/kg)+butorphanol (1mg/kg) for premedication, whereas the control group was induced solely with 6% sevoflurane via mask. Anaesthesia was maintained with sevoflurane in both groups. Reflex responses were assessed during the premedication and recovery phases. Intraoperative vital parameters were monitored at 0, 5, 15, 30, and 60 minutes. Cardiovascular function was assessed using electrocardiography (ECG) and echocardiography. Results: Reflex response times during the premedication and recovery phases differed significantly between the experimental and control groups (p<0.05). Intraoperatively heart rates, respiratory rates, body temperature, end-tidal CO₂ (EtCO₂), and aortic peak velocity (APV) values did not differ significantly, while SpO₂ at 15 minutes and sevoflurane concentrations at 0 and 5 minutes showed significant differences (p<0.05). Repeated measures revealed no significant differences in respiratory rate, body temperature, SpO₂, EtCO₂, or APV. However, sevoflurane concentration, heart rate, and certain ECG parameters were significantly different (p<0.05). Conclusions: Intranasal midazolam-butorphanol administration was well tolerated, providing more stable intraoperative vital parameters and reducing the requirement for sevoflurane. These findings indicate that this combination and its administration route represent a safe and effective premedication approach in buzzards, potentially offering several advantages during the maintenance of sevoflurane anaesthesia.