Synthesis, Characterization and Anti-inflammatory Activity of New 5-(3,4-Dichlorophenyl)-2-(aroylmethyl)thio-1,3,4-oxadiaxoles

KÖKSAL M., Bilge S. S., Bozkurt A., Sahin Z. S., Isik S., Erol D. D.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, vol.58, no.10, pp.510-514, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 10
  • Publication Date: 2008
  • Journal Name: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Index Chemicus (IC)
  • Page Numbers: pp.510-514
  • Keywords: 1,3,4-oxadiazoles, anti-inflammatory activity, S-alkylation, synthesis, X-ray crystallography, SUBSTITUTED 1,3,4-OXADIAZOLES, IN-VITRO, CYCLOOXYGENASE-2, INHIBITORS, AGENTS, INFLAMMATION, DERIVATIVES, VALDECOXIB, ESTER
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Several 5-(3,4-dichlorophenvi)-2(aroylmethyl)thio-1,3,4-oxadiazoles were synthesized and characterized by elemental analyses, IR and nuclear magnetic resonance spectra. All compounds were evaluated for anti-inflammatory activity by determining their ability to provide protection against carregeenan-induced edema in rat paw. in addition, ulcerogenic activity was determined. The anti-inflammatory data scoring showed that compounds 5e, 5f and 5g, at the dose of 100 mg/kg, exhibited anti-inflammatory activity, which for compound 5f was comparable to that of the reference drug indometacin WAS 53-86-1).