Akademik Veri Yönetim Sistemi
SINGAPORE MEDICAL JOURNAL, cilt.60, sa.4, ss.210-215, 2019 (SCI-Expanded, Scopus)
INTRODUCTION In patients undergoing haemodialysis, cardiovascular mortality and morbidity, characterised by accelerated atherosclerosis and increased inflammation, are elevated. Salusins are newly defined molecules in the atherosclerotic processes, and while salusin-alpha (Sal-alpha) acts as an antiatherogenic factor, salusin-beta (Sal-beta) has a proatherogenic role. Their roles are as yet undefined in patients undergoing haemodialysis. METHODS In this cross-sectional study, salusin levels, carotid intima-media thickness (CIMT) from the common carotid artery and pulse wave velocity (PWV) were measured for 180 patients undergoing haemodialysis and 90 healthy controls. RESULTS Mean Sal-alpha and Sal-beta levels in patients undergoing haemodialysis (Sal-alpha: 726.4 +/- 578.7 pg/mL; Sal-beta: 1,080.4 +/- 757.1 pg/mL) and healthy controls (Sal-alpha: 325.8 +/- 303.7 pg/mL; Sal-beta: 268.1 +/- 409.0 pg/mL) were determined. Negative correlation was observed between Sal-alpha levels and CIMT (patients undergoing haemodialysis: r = -0.330, p < 0.0001; healthy controls: r = -0.223, p = 0.035) and PWV (patients undergoing haemodialysis: r = -0.210, p = 0.005; healthy controls: r = -0.378, p < 0.0001) in both groups. In patients undergoing haemodialysis, positive correlation was observed between Sal-beta/Sal-alpha ratio and CIMT (r = 0.190, p = 0.012) and PWV (r = 0.155, p = 0.041). On subgroup analysis, Sal-a levels were found to be low in patients with diabetes mellitus. CONCLUSION Patients undergoing haemodialysis have higher Sal-beta and Sal-alpha levels, and their higher Sal-beta/Sal-alpha ratio, in comparison with healthy controls, might have cardiovascular risk implications.