E-CADHERN AND Ki-67 EXPRESSION IN COLORECTAL CARCINOMAS AND THEIR RELATIONSHIP WITH STAGE HISTOLOGICAL SUBTYPE AND GRADE

Kefeli M., Karagöz F., Baris S., Yıldız L., Aydin O., Kandemir B.

TURKISH JOURNAL OF PATHOLOGY, vol.21, no.1-2, pp.8-10, 2005 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1-2
  • Publication Date: 2005
  • Journal Name: TURKISH JOURNAL OF PATHOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.8-10
  • Keywords: Colorectal carcinoma, aderocarninoma, mocincus carcinoma, E-cadnerin, Ki-67, CANCER, GENE
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

In this study tissue slides Irom 102 colorectal resection specimens examined between 1998-2002 in he Department cl Pathology. Faculty ol medicine. Ondokuz Mayis University were retrospectively reevaluated. E-cacterin and Ki-67 expression were demonstred immnochistochemically and relationship of E-cadheren and Ki-57 expression with differentiation. histological subtype and stage were investigated. E-cadheren expression was seen in 89 of 102 (87%) colorectal adendocarcinamas and mucincus carninomas. Twentythree cases were (+), 32 cases (++) and 34 cases (+++), ki-67 expressuib was seen in 86 cases (84%) with a mean value of 16.7%. there was a relationship betweeen E-cadherin and Ki-67 expression and tumor differentiation. However no relationship between E-cadherin and Ki-67 index with tumor stage and histological subtype was found.