Plasma Atherogenic Index Predicts Malignant Arrhythmias in Non-ST-Elevation Myocardial Infarction
EURASIAN JOURNAL OF MEDICINE, cilt.58, sa.2, 2026 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 58 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.5152/eurasianjmed.2026.251315
- Dergi Adı: EURASIAN JOURNAL OF MEDICINE
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, Directory of Open Access Journals, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO), Health Research Premium Collection (ProQuest)
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
Background: Malignant ventricular arrhythmias are serious complications of non-ST-elevation myocardial infarction. The plasma atherogenic index, derived from triglyceride and high-density lipoprotein cholesterol, reflects atherogenic dyslipidemia. Its role in predicting malignant arrhythmias is unclear. The primary aim of this study was to determine whether the plasma atherogenic index independently predicts malignant ventricular arrhythmias in patients with non-ST-elevation myocardial infarction. Methods: A total of 502 patients with non-ST-elevation myocardial infarction admitted between January 2024 and January 2025 were retrospectively analyzed. Patients were grouped by arrhythmia occurrence and tertiles of the plasma atherogenic index. Logistic regression identified predictors of arrhythmias. Cox regression identified predictors of malignant arrhythmias. Receiver operating characteristic analysis assessed discriminative performance, and Kaplan-Meier analysis evaluated survival. Results: Malignant ventricular arrhythmias occurred in 47 patients (9.4%). They had significantly higher plasma atherogenic index values (0.48 +/- 0.35 vs. 0.21 +/- 0.29, P < .001). In multivariable analysis, multivessel disease, neutrophil, troponin T, low-density lipoprotein cholesterol, reduced ejection fraction, and the plasma atherogenic index independently predicted arrhythmias. For mortality, no-reflow, troponin T, malignant arrhythmia, and the plasma atherogenic index (hazard ratio 1.342, 95% confidence interval 1.211-1.487, P = .006) were independent predictors. The plasma atherogenic index had the highest discriminative value (area under the curve 0.721 for arrhythmias; 0.709 for mortality) with a cut-off of 0.32 (sensitivity 68%, specificity 68%). Kaplan-Meier analysis showed lower survival in the highest tertile. Conclusion: Elevated plasma atherogenic index independently predicts malignant arrhythmias and shortterm mortality in non-ST-elevation myocardial infarction. As a simple, widely available lipid marker, it may improve risk stratification in high-risk patients.