Assessment of MMP-1, MMP-8 and TIMP-2 in experimental periodontitis treated with kaempferol

BALLI U., Özkan Çetinkaya B., Keles G. C., Keles Z. P., Guler S., Ünlü Söğüt M., ...Daha Fazla

JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, cilt.46, sa.2, ss.84-95, 2016 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5051/jpis.2016.46.2.84
  • Dergi Adı: JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.84-95
  • Anahtar Kelimeler: Enzyme-linked immunosorbent assay, Histology, Kaempferol, Periodontal disease, Rats, GINGIVAL CREVICULAR FLUID, MATRIX METALLOPROTEINASES, MESSENGER-RNA, TISSUE INHIBITORS, GENE-EXPRESSION, GINKGO-BILOBA, DISEASE, CELLS, ACTIVATION, FLAVONOIDS
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Purpose: The objective of this study was to investigate the effect of a dietary flavonoid, kaempferol, which has been shown to possess antiallergic, anti-inflammatory, anticarcinogenic, and antioxidant activities on the periodontium by histomorphometric analysis and on gingival tissue matrix metalloproteinase-1 (MMP-1), MMP-8, and tissue inhibitor of metalloproteinase-2 (TIMP-2) by biochemical analysis of rats after experimental periodontitis induction.