Proconvulsant Effect of Papaverine on Penicillin-Induced Epileptiform Activity in Rats

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Marangoz A. H., Kocacan S. E., Him A., Kuruoglu E., Çokluk C., MARANGOZ C.

TURKISH NEUROSURGERY, vol.28, no.3, pp.479-482, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.5137/1019-5149.jtn.19703-17.2
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.479-482
  • Keywords: Epilepsy, Female rat, Papaverine, Penicillin, ANEURYSMAL SUBARACHNOID HEMORRHAGE, CEREBRAL VASOSPASM, INTRAARTERIAL PAPAVERINE, ENDOVASCULAR MANAGEMENT, INDUCED SEIZURES, NITRIC-OXIDE, EPILEPSY, INHIBITION, ADENOSINE
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

AIM: Papaverine is a vasodilator agent that is an opium alkaloid. It exhibits its effects by inhibiting the phosphodiesterase enzyme. Papaverine administration is widely used to avoid symptomatic vasospasm after subarachnoid hemorrhage. We aimed, in this research, to study the effects of papaverine on the epileptic discharges stimulated by penicillin.