Antiproliferative activity of pentadeca-(8E, 13Z) dien-11-yn-2-one and (E)-1,8-pentadecadiene from Echinacea pallida (Nutt.) Nutt. roots

Yaglıoglu A. S., Akdulum B., Erenler R., Demirtas İ., Telci I., Tekin S.

Medicinal Chemistry Research, vol.22, no.6, pp.2946-2953, 2013 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.1007/s00044-012-0297-2
  • Journal Name: Medicinal Chemistry Research
  • Journal Indexes: Scopus
  • Page Numbers: pp.2946-2953
  • Keywords: Antiproliferative activity, C6 cancer cell line, Echinacea pallida, HeLa cancer cell line, Isolation
  • Ondokuz Mayıs University Affiliated: No

Abstract

Several species of Echinacea, a perennial plant which belongs to the Asteraceae family, possess medicinal properties and are currently used in phytotherapy. In the present study, antiproliferative activity of methanol extract and isolated structures of pentadeca-(8E, 13Z)-dien-11-yn-2-one 1 and (E)-1,8-pentadecadiene 2 from Echinacea pallida roots on C6 cells (Rat Brain tumor cells) and HeLa cells (human uterus carcinoma) was investigated in vitro. Antiproliferative effect of the extract, isolated compounds, and cisplatin were tested at 5, 10, 20, 30, 40, 50, 75, and 100 μg ml -1 using BrdU Cell Proliferation ELISA. The methanol extract and Compound 1 significantly inhibited proliferation of HeLa and C6 cancer cell lines. © 2012 Springer Science+Business Media New York.