Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy

Enes Coşkun M., Kervancioǧlu M., Öztuzcu S., Yilmaz Coşkun F., Ergün S., Başpinar O., ...Daha Fazla

Biomarkers, cilt.21, sa.1, ss.56-61, 2016 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/1354750x.2015.1118533
  • Dergi Adı: Biomarkers
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.56-61
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

Context: Dilated cardiomyopathy (DCM) is the most common cardiomyopathy in children. MicroRNAs (miRNA) are small RNAs which have regulatory functions in many biological processes.Objective: We aimed to determine miRNA expression levels in plasma of children with DCM.Materials and methods: Plasma expression levels of 379 miRNAs were compared between 23 DCM and 26 healthy children.Results: The expression levels of miR-618, miR-875-3p, miR-205, miR-194, miR-302a, miR-147, and miR-544 were found decreased. The expression levels of miR-518f and miR-454 were found increased in DCM patients.Discussion: miRNA level differences may provide the chance of using these miRNAs as new biomarkers.