Research Information System
BURNS, vol.28, no.8, pp.760-764, 2002 (SCI-Expanded)
The purpose of this study was to determine the effect of recombinant human growth hormone (rhGH) on serum constitutive proteins, cytokines, P-selectin, and insulin-like growth factor (IGF-1) in the thermally injured rats. Sprague-Dawley rats (64 males) were given 30% total body surface area full thickness scald burn. They were randomly divided to receive either 2.5 mg/kg per day im rhGH or saline (control). Rats were sacrified on postburn days 1, 2, 5, and 7, and serum constitutive proteins, cytokines, P-selectin, and IGF-1 levels were measured. Serum IGF-1 levels were increased on days 2, 5, or 7 after burn in rhGH-treated rats compared with controls (P < 0.001, < 0.01 and < 0.001, respectively). Serum transferrin and albumin levels were increased on days 7 after burn in rhGH-treated rats compared with controls (P < 0.05). The cytokines increased after thermal injury. The rhGH decreased serum levels of tumor necrosis factor-a on postburn days 1 compared with controls (P < 0.001). Serum levels of interleukin-1 were decreased on days 1 and 2 after burn in rhGH treated rats compared with controls (P < 0.001, < 0.01, respectively). Rats receiving rhGH showed significantly increased P-selectin levels at 5 and 7 postburn days compared with controls (P < 0.001). Our data indicate that rhGH, given after thermal injury, increased albumin, transferrin, IGF-1, and P-selectin levels and decreased serum tumor necrosis factor-alpha and interleukin-1 levels. (C) 2002 Elsevier Science Ltd and ISBI. All rights reserved.