Serum osteopontin and CD44 levels in lymphoreticular malignancies in children

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Elli M., Dagdemir A., Bozkurt C., Pinarli F. G., Duzgun A., Ozmen Z. C., ...More

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.113, no.9, pp.534-538, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 113 Issue: 9
  • Publication Date: 2012
  • Doi Number: 10.4149/bll_2012_120
  • Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.534-538
  • Keywords: osteopontin, CD44, lymphoma, leukemia, children, PROSTATE-CANCER CELLS, NON-HODGKINS-LYMPHOMA, BREAST-CANCER, HEPATOCELLULAR-CARCINOMA, ADHESION MOLECULES, PLASMA OSTEOPONTIN, TUMOR PROGRESSION, EPITHELIAL-CELLS, COLON-CANCER, EXPRESSION
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Objective: Osteopontin (OPN) is an adhesive glycoprotein that interacts with a variety of cell surface receptors, including several integrins and CD44. OPN is expressed and secreted by numerous human malignancies. CD44 play an important role in tumor growth and metastasis. We aimed to evaluate serum levels of osteopontin and CD44 in patients with lymphorethicular malignancies in childhood.