t(6;9)(p23;q34) Presenting Acute Myeloid Leukemia in a Child With an Unsuspected 45,X/46,X,derY [?t(Yp;Yq)] Chromosomal Constitution: Yet Another Y Chromosome Overdosage and Malignancy Association

Ogur G., Duru F., Ozyurek E., Fisgin T.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, vol.34, no.6, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1097/mph.0b013e318238866f
  • Journal Name: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: 45,X/46,X,derY, acute myeloid leukemia, t(6;9)(p23;q34), variant Turner syndrome, ACUTE LYMPHOBLASTIC-LEUKEMIA, ACUTE MYELOGENOUS LEUKEMIA, OF-THE-LITERATURE, KLINEFELTER-SYNDROME, DYSGENETIC GONADS, TURNER-SYNDROME, HEMATOLOGIC MALIGNANCIES, TRANSLOCATION 6-9, 2 GENES, GONADOBLASTOMA
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Development of leukemia in patients with sexual chromosome abnormalities is relatively rare and mostly involves cases of monosomy X, Turner syndrome. Here, we report on a child having a 45,X/46,X,derY [?t(Yp;Yq)] chromosomal constitution (variant Turner syndrome) presenting with concordant acute myeloid leukemia and a rarely seen clonal neoplasic cell lineage-related karyotype, t(6;9)(p23;q34).