The aim of the study was to investigate and compare the effects of N-acetyl cysteine (NAC) and resveratrol on acute phase response in rats with experimentally induced arthritis. In this study, 30 Sprague-Dawley mature rats were inoculated with two doses of Freund's Complete Adjuvant (FCA) by means of intradermal injections into the left hind claws of all rats. Rats were divided into three groups at the 15th day of arthritis formation process, 15% ethyl alcohol was applied to group 1 rats via i.p., NAC was applied to group 2 rats via i.p. and resveratrol was applied to group 3 rats via i.p. for 21 days. Following the experimental period, blood was collected from the rats and then they were euthanized, and the joint tissues were collected. No significant differences were found in serum TNF-alpha, IL-beta, IL-6 levels and ADA activity and a decrease was determined in MDA levels in the resveratrol group. According to histopathological result, decreases in the loss of cellularity and adhesion were determined as P<0.05 and P<0.01, respectively in group received resveratrol. Compared to arthritis group, the decrease (P<0.05) in safranin-O ortochromatosis in group 2 and 3 was found. However the recovery from synovial inflammation (P<0.01) was determined both in NAC and resveratrol groups. The best recovery rate was recorded in the resveratrol group. In conclusion, resveratrol may be suggested to use in arthritis therapy alternative to NAC.