Pseudorelapse in acute myelomonocytic leukemia after high dose methylprednisolone

Albayrak D.

Leukemia Research, cilt.18, sa.1, ss.61-62, 1994 (Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1016/0145-2126(94)90010-8
  • Dergi Adı: Leukemia Research
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.61-62
  • Anahtar Kelimeler: high dose, Leukemia, methylprednisolone, myelomonocytic, relapse
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

High dose methylprednisolone (HDMP) has been used both in induction treatment and in leukopenia of acute leukemia. We report the case of a 14-year-old girl with acute myelomonocytic leukemia (AMML) who developed a pseudorelapse after receiving an oral HDMP trial (30 mg/kg/day PO in the morning for 15 days) to overcome neutropenia. She presented with severe bone pain at the end of treatment. Bone marrow examination revealed 53% young promyelocytes (some with a large nucleolus), 2% myeloblast, 5% monocyte, and increased cellularity. Bone pain and promyelocytes regressed spontaneously while maintenance treatment continues. We advise that a pseudorelapse must be borne in mind after MDMP and probably GM-CSF treatments in acute leukaemias. © 1993.