RESEARCH ON CHEMICAL INTERMEDIATES, vol.45, no.9, pp.4543-4554, 2019 (SCI-Expanded)
Article / Article
RESEARCH ON CHEMICAL INTERMEDIATES
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC), Current Chemical Reactions (CCR)
Chlorokojic acid, Isocyanides, Acetylene esters, Nucleophilic addition, 4H-Pyran, 4, 8-Dihydropyrano[3, 2-b]-pyran, Intramolecular H bond, Inversion dimers, DERIVATIVES, ANTICONVULSANT, ISOCYANIDES
Ondokuz Mayıs University Affiliated:
A safe, green and convenient process was developed for the synthesis of a novel group of 4,8-dihydropyrano[3,2-b]-pyrans by dialkyl acetylenedicarboxylates and alkyl isocyanides being trapped by chlorokojic acid in good to excellent yields at ambient temperature. Characterization of all structures was carried out by FT-IR and H-1 and C-13 NMR spectrometers, and two compounds were analyzed using X-ray diffraction technique. Crystal structures showed an intramolecular hydrogen bond and stacking of the dimeric (RS) molecules with the unit cell along the a-axis.