Preparation, structure elucidation, and antioxidant activity of new bis(thiosemicarbazone) derivatives

Yakan H.

TURKISH JOURNAL OF CHEMISTRY, cilt.44, sa.4, ss.1085-1117, 2020 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3906/kim-2002-76
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1085-1117
  • Anahtar Kelimeler: Thiosemicarbazides, Schiff bases, DPPH, structure-activity relationship, spectroscopic methods, METAL-COMPLEXES, SPECTROSCOPIC CHARACTERIZATION, SCHIFF-BASES, ANTICANCER
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Schiff-base-bearing new bis(thiosemicarbazone) derivatives were prepared from terephthalaldehyde and various thiosemicarbazides. FT-IR, H-1 NMR, C-13 NMR, and UV-Vis spectroscopic methods and elemental analysis were used to elucidate the identification of the synthesized molecules. The in vitro antioxidant activity of the synthesized compounds was analysed with the 1,1-diphenyl-2-picryl hydrazyl free-radical-trapping process. The synthesized compounds exhibited lower antioxidant activity than the standard ascorbic acid. IC50 values of the synthesized molecules measured from 3.81 +/- 0.01 to 29.05 +/- 0.11 mu M. Among the synthesized compounds, compound 3 had the best antioxidant activity. Moreover, this study explained the structure-activity relationship of the synthesized molecules with different substituents in radical trapping reactions.