Preparation, structure elucidation, and antioxidant activity of new bis(thiosemicarbazone) derivatives

Yakan H.

TURKISH JOURNAL OF CHEMISTRY, vol.44, no.4, pp.1085-1117, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.3906/kim-2002-76
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1085-1117
  • Keywords: Thiosemicarbazides, Schiff bases, DPPH, structure-activity relationship, spectroscopic methods, METAL-COMPLEXES, SPECTROSCOPIC CHARACTERIZATION, SCHIFF-BASES, ANTICANCER
  • Ondokuz Mayıs University Affiliated: Yes


Schiff-base-bearing new bis(thiosemicarbazone) derivatives were prepared from terephthalaldehyde and various thiosemicarbazides. FT-IR, H-1 NMR, C-13 NMR, and UV-Vis spectroscopic methods and elemental analysis were used to elucidate the identification of the synthesized molecules. The in vitro antioxidant activity of the synthesized compounds was analysed with the 1,1-diphenyl-2-picryl hydrazyl free-radical-trapping process. The synthesized compounds exhibited lower antioxidant activity than the standard ascorbic acid. IC50 values of the synthesized molecules measured from 3.81 +/- 0.01 to 29.05 +/- 0.11 mu M. Among the synthesized compounds, compound 3 had the best antioxidant activity. Moreover, this study explained the structure-activity relationship of the synthesized molecules with different substituents in radical trapping reactions.