Changing of antioxidant enzyme activity on the biliary obstructed rats treated with resveratrol

Cenesiz S., Yarim G. F., Karabulut A. B., Ara C.

DEUTSCHE TIERARZTLICHE WOCHENSCHRIFT, vol.114, no.9, pp.345-348, 2007 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 114 Issue: 9
  • Publication Date: 2007
  • Doi Number: 10.2377/0341-6593-114-345
  • Journal Name: DEUTSCHE TIERARZTLICHE WOCHENSCHRIFT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.345-348
  • Keywords: bile duct ligations, biliary cirrhosis, fibrosis, oxidative stress, resveratrol, NITRIC-OXIDE, OXIDATIVE-STRESS, LIVERS, DAMAGE
  • Ondokuz Mayıs University Affiliated: No

Abstract

The aim of this study was to evaluate the role of antioxidant enzyme activity and nitric oxide levels induced by 28 day biliary obstruction in the rat. A total of 21 young Swiss albino rats were divided in to 3 groups. Bile duct ligations, bile duct ligations plus resveratrol, sham operated. Bile duct ligations plus resveratrol group received 10 mg/kg dose of resveratrol intraperitonealy once daily throughout for 28 days. Liver damage and cholestasis were determined by biochemical examination. SOD, CAT and GSH-PX activity decreased in BDL group compared with shame opareted groups (p < 0.001). NO levels increased in BDL groups compared with shame opareted groups (p < 0.001). SOD, CAT and GSH-PX activity was found higher in BDL+resveratrol treated groups than BDL groups (p < 0.001). In addition this NO levels decreased in BDL+resveratrol treated groups than BDL groups (p < 0.001). In conclusion, it is thought that resveratrol may be used as a protective agent in biliary obstructions; however, further clinical and experimental studies are needed to verify its antioxidative and hepatoprotective effects.