Tetrakis- [3-(trimethoxysilanyl)-propyl]-1,2,3-triazoles grafted to a naphthalene core: Synthesis, characterisation and biological activity evaluation


Singh G., Markan P., Poyraz E. B., Sharma S., Sharma D., Dege N., ...Daha Fazla

JOURNAL OF MOLECULAR STRUCTURE, cilt.1352, 2026 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1352
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1016/j.molstruc.2025.144616
  • Dergi Adı: JOURNAL OF MOLECULAR STRUCTURE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Germination is a crucial process that influences seedling development and can alter nutrient availability in plants. To explore the effects of organosilane derivatives on this process, the naphthalene-1,5-diamine-coupled triethoxy-organosilanes were synthesized via Click chemistry and characterized using several spectroscopic methods, including FT-IR, NMR spectroscopy (1H &13C), and mass spectrometry (MS). Their molecular structures were further confirmed by X-ray diffraction (XRD). Wheat (Triticum aestivum) is one of the world's most important staple grains and a primary source of calories and protein for the global population. Their effects were assessed on wheat through wheat through seedling-growth. The effects of different concentrations of compounds 1b, 2b on various plant bioassay parameters were evaluated and compared with a control group.Among the concentrations tested, 7.5 mg L-1 resulted in the most pronounced improvements in growth metrics compared with the control. In addition, the synthesized ligands exhibited strong anticancer effects, lowering cell viability relative to untreated controls.