Akademik Veri Yönetim Sistemi
Tropical Journal of Natural Product Research, cilt.8, sa.6, ss.7374-7381, 2024 (Scopus)
Fagonia longispina (Zygophyllaceae family) has long been employed in traditional practices for combating cancer, with scientific research yielding insights into its biological impact. This study aimed to validate the potential of this plant by evaluating the antioxidant, antiproliferative, and antibacterial properties of the n-butanol, ethyl acetate, and chloroform extracts of F. longispina (BuE, EAE, and ChE, respectively). The most significant total phenolics (TPC) were recorded in EAE (377 ± 24.33 µg GAE/mg extract), whereas BuE showed the most important quantity of flavonoids (TFC) (87.14 ± 1.56 µg QE/mg extract). Outcomes indicated that EAE displayed the highest DPPH (2, 2-diphenyl-1-picrylhydrazyl) scavenging effect (IC50 = 37.82 ± 7.83 μg/mL) compared to BuE (IC50 = 59.49 ± 6.16 μg/mL, p = 0.0197) and ChE (IC50 =111.89 ± 6.10 μg/mL, p = 0.0002). Despite the increased activity of EAE, it remained lower than ascorbic acid (IC50 = 5.00 ± 0.1 µg/mL, p = 0.02). Moreover, EAE was the strongest at scavenging free radicals from FeSO4 (IC50 = 126.66 ± 5.76 µg/mL). All extracts except BuE showed antiproliferative efficacy against HeLa and HT-29 cells. Various bacterial strains underwent testing to demonstrate their antibacterial effectiveness, which was assessed by measuring inhibition zones. The results showed enjoyable antimicrobial activity against gram-positive bacteria. In conclusion, this study proves the application of F. longispina in traditional medicine. Furthermore, the results from the antioxidant tests confirmed that F. longispina had an antioxidant effect and may be used as a new natural antioxidant in therapy.