Hypothermia is not therapeutic in a neonatal piglet model of inflammation-sensitized hypoxia-ischemia

Martinello, Kathryn; Meehan, Christopher; Avdic-Belltheus, Adnan; Lingam, Ingran; Mutshiya, Tatenda; Yang, Qin; Akın, Mustafa; Price, David; Sokolska, Magdalena; Bainbridge, Alan; Hristova, Mariya; Tachtsidis, Ilias; Tann, Cally; Peebles, Donald; Hagberg, Henrik; Wolfs, Tim; Klein, Nigel; Kramer, Boris; Fleiss, Bobbi; Gressens, Pierre; Golay, Xavier; Robertson, Nicola

doi:10.1038/s41390-021-01584-6

Hypothermia is not therapeutic in a neonatal piglet model of inflammation-sensitized hypoxia-ischemia

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Martinello K. A., Meehan C., Avdic-Belltheus A., Lingam I., Mutshiya T., Yang Q., ...More

PEDIATRIC RESEARCH, vol.91, no.6, pp.1416-1427, 2022 (SCI-Expanded)

Publication Type: Article / Article
Volume: 91 Issue: 6
Publication Date: 2022
Doi Number: 10.1038/s41390-021-01584-6
Journal Name: PEDIATRIC RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
Page Numbers: pp.1416-1427
Ondokuz Mayıs University Affiliated: Yes

Abstract

BACKGROUND: Perinatal inflammation combined with hypoxia-ischemia (HO exacerbates injury in the developing brain. Therapeutic hypothermia (HT) is standard care for neonatal encephalopathy; however, its benefit in inflammation-sensitized HI (IS-HI) is unknown.