POLYMORPHISM IN THE H-RAS PROTO-ONCOGENE IN CASES OF URINARY BLADDER CANCER
TURKISH JOURNAL OF UROLOGY, vol.32, no.1, pp.14-18, 2006 (ESCI, Scopus)
- Publication Type: Article / Article
- Volume: 32 Issue: 1
- Publication Date: 2006
- Journal Name: TURKISH JOURNAL OF UROLOGY
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
- Page Numbers: pp.14-18
- Keywords: Bladder Cancer, H-ras proto-oncogene, single nucleotide polymorphism
- Ondokuz Mayıs University Affiliated: Yes
Abstract
Introduction: Ras proteins play role in signal transduction, cell division and differentiation. Ras protein is encoded by a gene located at 11p15.5 in human. The purpose of this study was to investigate the possible association of H-ras proto-oncogene T/C single nucleotide polymorphism at nucleotide sequence 81 with bladder cancer in Turkish population. Materials and Methods: We studied 59 patients with histologically verified bladder cancer and 74 healthy volunteers. The H-ras proto-oncogene polymorphism was determined by polymerase chain reaction based restriction fragment length polymorphism and agarose gel electrophoreses methods. Results: Findings seem to indicate that there is no association between the H-ras polymorphism at codon 81 and bladder cancer (OR, 1.531; % 95 CI, 0.69-3.42; P=0.26). Also there is no association between H-ras polymorphism and smoking, exposure to carcinogens and age. Conclusion: The H-ras polymorphism does not seem to play a role in Bladder Cancer in Turkish population.