Immediate versus delayed primary nerve repair in the rabbit sciatic nerve

PİŞKİN A., Altunkaynak B. Z., Citlak A., Sezgin H., Yazici O., Kaplan S.

NEURAL REGENERATION RESEARCH, vol.8, no.36, pp.3410-3415, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 36
  • Publication Date: 2013
  • Doi Number: 10.3969/j.issn.1673-5374.2013.36.006
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3410-3415
  • Keywords: neural regeneration, delayed peripheral nerve repair, sciatic nerve, peripheral nerve injury, stereology, microscopy, biomechanics, neuroregeneration, HIGH-FAT DIET, PERIPHERAL-NERVE, PLATELET GEL, ULNAR NERVES, FEMALE RAT, IN-VITRO, REGENERATION, EPINEURIAL, STRENGTH, EXPOSURE
  • Ondokuz Mayıs University Affiliated: Yes


It is well known that peripheral nerve injury should be treated immediately in the clinic, but in some instances, repair can be delayed. This study investigated the effects of immediate versus delayed (3 days after injury) neurorrhaphy on repair of transected sciatic nerve in New Zealand rabbits using stereological, histomorphological and biomechanical methods. At 8 weeks after immediate and delayed neurorrhaphy, axon number and area in the sciatic nerve, myelin sheath and epineurium thickness, Schwann cell morphology, and the mechanical property of nerve fibers did not differ obviously. These results indicate that delayed neurorrhaphy do not produce any deleterious effect on sciatic nerve repair.