Association of transforming growth factor beta 1 gene polymorphism with rheumatoid arthritis in a Turkish population

Alaylı, Gamze; Kara, Nurten; Tander, Berna; Canturk, Ferhan; Güneş, Sezgin; Bagci, Hasan

doi:10.1016/j.jbspin.2008.02.012

Association of transforming growth factor beta 1 gene polymorphism with rheumatoid arthritis in a Turkish population

Alaylı G., Kara N., Tander B., Canturk F., Güneş S., Bagci H.

JOINT BONE SPINE, cilt.76, sa.1, ss.20-23, 2009 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 76 Sayı: 1
Basım Tarihi: 2009
Doi Numarası: 10.1016/j.jbspin.2008.02.012
Dergi Adı: JOINT BONE SPINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.20-23
Anahtar Kelimeler: Rheumatoid arthritis, Polymorphism, Transforming growth factor beta 1, GROWTH-FACTOR-BETA-1 GENE, TRANSFORMING-GROWTH-FACTOR-BETA-1 GENE, SYNOVIAL TISSUES, DISEASE, SUSCEPTIBILITY, TGF-BETA-1, CYTOKINES, PROGRESSION, PREDICTOR, SEVERITY
Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Objective: Cytokine genes play important role, in the pathogenesis of rheumatoid arthritis (RA). In RA, the plasma and synovial fluid levels of transforming growth factor beta 1 (TGF beta 1) have been shown to be raised. The aim of this study was to investigate the relationship between the TGF beta 1 T869C polymorphism and RA in a Turkish population.