Evaluation of the effectiveness of the membrane composed of biodegradable polycaprolactone and polyglycolic acid layers in guided bone regeneration
BMC Oral Health, cilt.26, sa.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1186/s12903-026-08853-y
- Dergi Adı: BMC Oral Health
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Anahtar Kelimeler: 3D printing, Bone regeneration, Histology, Polycaprolactone, Polyglycolic acid, Rats
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
Background: This study aimed to evaluate the efficacy of a biodegradable membrane composed of polycaprolactone (PCL) and polyglycolic acid (PGA) for guided bone regeneration in bone defects. Methods: Twelve Wistar albino rats were initially included in the study. During follow-up, 3 rats were excluded. To maintain the planned sample size, these animals were replaced with 3 additional rats. Consequently, a total of 15 rats were used, and the final statistical analyses were based on 12 rats. Twenty-four standardized bilateral parietal bone defects were created and randomly allocated to four groups. Defects received either 3D-printed PCL membranes or PCL membranes coated on the inner surface with PGA (PCL/PGA). Control defects received PCL membranes alone. Group 1 received PCL/PGA with a human-derived freeze-dried bone graft, an equine xenograft, and autologous blood. Group 2 received PCL/PGA with autologous blood. Group 3 received PCL with autologous blood. Six rats were euthanized at 4 weeks and six at 8 weeks. Histopathological and stereological analyses were performed to assess newly formed bone volume. Results: At week 4, Group 2 showed significantly greater newly formed bone volume and total tissue volume than all other groups (p < 0.001). At week 8, newly formed bone volume in Group 2 remained significantly greater than in Groups 1 and 3 (p < 0.001) but did not differ from the control group (p > 0.05). Conclusion: In this GBR model, the PGA-coated PCL membrane enhanced new bone formation during the early phase of bone regeneration.