Activity of Platelet Activating Factor Acetylhydrolase Following Phase I Periodontal Therapy

Keles G. C., Cetinkaya B. O., Pamuk F., Balli U.

WEST INDIAN MEDICAL JOURNAL, vol.62, no.1, pp.62-67, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 1
  • Publication Date: 2013
  • Journal Name: WEST INDIAN MEDICAL JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.62-67
  • Keywords: Chronic periodontitis, gingival crevicular fluid, periodontal therapy, platelet activating factor acetylhydrolase, GINGIVAL CREVICULAR FLUID, PHOSPHOLIPASE A(2), PAF-AH, DISEASE, TISSUE, SURGERY
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Objective: Elevated levels of platelet activating factor (PAF), a potent inflammatory mediator, in periodontal disease and decreased PAP levels following periodontal surgical therapy have been previously detected in gingival tissues and gingival crevicular fluid (GCF). Platelet activating factor acetylhydrolase (PAF-AH) is a calcium-independent phospholipase A(2) that catalyses the hydrolysis of PAF, thereby inactivating this mediator The hypothesis, a relationship between activity of PAP-All and healing following periodontal therapy, was tested by detecting activity of PAF-AH in GCF samples collected from sites that had undergone phase I periodontal therapy with generalized chronic periodontitis.