Mono and dinuclear copper(II) naproxenato complexes containing 3-picoline and 4-picoline: synthesis, structure, properties, catechol oxidase, and antimicrobial activities


ÇAĞLAR S., Adiguzel E., SARIBOĞA B., Temel E., Buyukgungor O.

JOURNAL OF COORDINATION CHEMISTRY, vol.67, no.4, pp.670-683, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.1080/00958972.2014.891198
  • Journal Name: JOURNAL OF COORDINATION CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.670-683
  • Keywords: Copper(II) complex, Antimicrobial activity, Naproxen, Catechol oxidation, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, CRYSTAL-STRUCTURE, SPECTROSCOPIC PROPERTIES, MOLECULAR-STRUCTURE, MAGNETIC-PROPERTIES, DICOPPER COMPLEXES, BONDING PROPERTIES, H-BPMP, LIGANDS, OXIDATION
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Mononuclear and dinuclear copper(II) complexes [Cu-2(mu-nap)(4)(3-pic)(2)] (1) and [Cu(nap)(2)(H2O)(4-pic)(2)] (2) have been synthesized in the presence of 3-picoline and 4-picoline. Two complexes were characterized by FT-IR, UV-vis spectroscopic methods and their thermal stabilities were determined by TG/DTA/DTG techniques. The crystal structures of 1 and 2 were established by X-ray analysis. X-ray structure analysis has shown that copper(II) has a distorted square-pyramidal geometry. Naproxenate is a bridging ligand in 1 and monodentate in 2. Two complexes have shown catalytic activity on oxidation of 3,5-di-tert-butylcatechol to 3,5-di-tert-butylquinone exhibiting saturation kinetics at high substrate concentrations. The complexes were also screened for antimicrobial activity against pathogenic bacteria and fungi. The complexes exhibited antimicrobial activity against Entrococcus faecalis and Candida albicans.