Is platelet-rich plasma improves the anastomotic healing in hyperthermic intraperitoneal chemotherapy with oxaliplatin: an experimental rat study

Buk O. F., Ocak S., Genç B., Avcı B., Uzuner H. O.

ANNALS OF SURGICAL TREATMENT AND RESEARCH, vol.98, no.2, pp.89-95, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 98 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.4174/astr.2020.98.2.89
  • Journal Name: ANNALS OF SURGICAL TREATMENT AND RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.89-95
  • Keywords: Anastomotic leak, Colonic neoplasms, Hyperthermia, Oxaliplatin, Platelet-rich plasma, CYTOREDUCTIVE SURGERY, PERITONEAL CARCINOMATOSIS, COLONIC ANASTOMOSIS, CANCER, SURVIVAL, STOMA
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Purpose: Hyperthermic intraperitoneal chemotherapy (HIPEC) is a novel treatment option for peritoneal surface malignancies. Due to cytotoxic effects of chemotherapeutic agents, anastomosis healing can be impaired and lead to leakage rates higher than conventional intestinal surgery. In this experimental study, we aimed to investigate the effects of platelet-rich plasma (PRP) on colonic anastomosis in rats that received HIPEC with oxaliplatin.