Lack of association between the G-2548A polymorphism of the leptin gene and psoriasis in a Turkish population

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Kara N., Aydın F., Şentürk N., Güneş S., Canturk M. T., Bagci H., ...More

INTERNATIONAL JOURNAL OF DERMATOLOGY, vol.46, no.12, pp.1271-1274, 2007 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 46 Issue: 12
• Publication Date: 2007
• Doi Number: 10.1111/j.1365-4632.2007.03324.x
• Journal Name: INTERNATIONAL JOURNAL OF DERMATOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1271-1274
• Ondokuz Mayıs University Affiliated: Yes

Abstract

Background Psoriasis is a multifactorial disease in which genetic and inflammatory factors play important roles. Leptin is classified as a cytokine and plays an important role in the regulation of the T-helper response. A common polymorphism in the promoter of the human leptin gene (G-2548A) may have a role in the pathogenesis of psoriasis.