INTERNATIONAL JOURNAL OF DERMATOLOGY, cilt.46, sa.12, ss.1271-1274, 2007 (SCI-Expanded)
Background Psoriasis is a multifactorial disease in which genetic and inflammatory factors play important roles. Leptin is classified as a cytokine and plays an important role in the regulation of the T-helper response. A common polymorphism in the promoter of the human leptin gene (G-2548A) may have a role in the pathogenesis of psoriasis.