Impact of Endothelial NOS VNTR Variant on Susceptibility to Diabetic Neuropathy and Type 2 Diabetes Mellitus

YİĞİT S., NURSAL A. F., UZUN S., Rustemoglu H., Dashatan P. A., Soylu H., ...More

CURRENT NEUROVASCULAR RESEARCH, no.5, pp.700-705, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2021
  • Doi Number: 10.2174/1567202617999201214230147
  • Journal Name: CURRENT NEUROVASCULAR RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Page Numbers: pp.700-705
  • Keywords: Endothelial NOS VNTR variant, diabetes mellitus, hyperglycemia, diabetic peripheral neuropathy, genotype, peripheral nerve, OXIDE SYNTHASE GENE, NITRIC-OXIDE, 4A/B POLYMORPHISM, ASSOCIATION, RISK, NEPHROPATHY, INTRON-4
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Purpose: The aim of this study was to evaluate whether the VNTR intron 4b/4a variant in the eNOS gene is associated with type 2 diabetes mellitus (T2DM) and DPN. Methods: A total of 598 subjects were enrolled in the study. eNOS VNTR 4b/4a variant was geno-typed by polymerase chain reaction (PCR) method. Results: eNOS VNTR intron 4b/4b genotype and b allele increased in patients with both DPN and T2DM compared healthy controls (p=0.0005, OR:1.94, p=0.000002, OR:4.10, respectively). 4a/4b genotype was more prevalent in controls than in DPN and T2DM patients (p=0.00008, OR:0.46; p=0.000004, OR:0.24, respectively). eNOS VNTR b allele was more common in DPN patients and T2DM patients compared with controls (p=0.007, p=0.00002, respectively). Conclusion: The eNOS VNTR "4b/4b" homozygous genotype and hence "4b"allele as a genetic risk factor for T2DM and DPN, which may serve as a useful marker of increased susceptibility to the risk of these disorders.