Synthesis and cytotoxic activity of some 1,2,4-triazoline-3-thione and 2,5-disubstituted-1,3,4-thiadiazole derivatives

Creative Commons License

KARAKUŞ S., ÇORUH U., Barlas-Durgun B., Vazquez-Lopez E. M., ÖZBAŞ S., Akbuga J., ...More

MARMARA PHARMACEUTICAL JOURNAL, vol.14, no.2, pp.84-90, 2010 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.12991/201014454
  • Journal Name: MARMARA PHARMACEUTICAL JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.84-90
  • Keywords: Cytotoxic activity, 1,2,4-triazoline-3-thione, 2,5-disubstituted-1,3,4-thiadiazole, mtt assay, x-ray crystallograpy
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

In this search, a series of 5-[4-(4-fluorobenzoylamino) phenyl]-2-substitutedamino- 1,3,4-thiadiazole (2a-g) and 5-[4-(4-fluorobenzoylamino) phenyl]-4-substituted-2,4-dihydro- 3H-1,2,4-triazo-le-3-thione (3a-f) derivatives were synthesized and characteristed by elemental analysis, UV-visible, IR, H-1-NMR, MS spectral data and X-ray crystallograpy (3b). Cytotoxic activity of six prototype compounds (2a, 2d, 2e, 3a, 3d and 3e) were evaluated by using HeLa (ATCC CCL-2) and normal cell lines according to procedures of MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] Assay [Cell Proliferation Kit I (MTT) Roche-Germany].