Synthesis and cytotoxic activity of some 1,2,4-triazoline-3-thione and 2,5-disubstituted-1,3,4-thiadiazole derivatives
MARMARA PHARMACEUTICAL JOURNAL, cilt.14, sa.2, ss.84-90, 2010 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 2
- Basım Tarihi: 2010
- Doi Numarası: 10.12991/201014454
- Dergi Adı: MARMARA PHARMACEUTICAL JOURNAL
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Sayfa Sayıları: ss.84-90
- Anahtar Kelimeler: Cytotoxic activity, 1,2,4-triazoline-3-thione, 2,5-disubstituted-1,3,4-thiadiazole, mtt assay, x-ray crystallograpy
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
In this search, a series of 5-[4-(4-fluorobenzoylamino) phenyl]-2-substitutedamino- 1,3,4-thiadiazole (2a-g) and 5-[4-(4-fluorobenzoylamino) phenyl]-4-substituted-2,4-dihydro- 3H-1,2,4-triazo-le-3-thione (3a-f) derivatives were synthesized and characteristed by elemental analysis, UV-visible, IR, H-1-NMR, MS spectral data and X-ray crystallograpy (3b). Cytotoxic activity of six prototype compounds (2a, 2d, 2e, 3a, 3d and 3e) were evaluated by using HeLa (ATCC CCL-2) and normal cell lines according to procedures of MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] Assay [Cell Proliferation Kit I (MTT) Roche-Germany].