Serum Zonulin Levels as an Early Biomarker in Predicting the Severity and Complications of Acute Pancreatitis

AVCIOĞLU U., Eruzun H.

EURASIAN JOURNAL OF MEDICINE, vol.55, no.1, pp.78-82, 2023 (ESCI) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.5152/eurasianjmed.2022.0272
  • Journal Name: EURASIAN JOURNAL OF MEDICINE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.78-82
  • Keywords: Acute pancreatitis, complications, zonulin, bacterial translocation, INTESTINAL PERMEABILITY, ORGAN FAILURE, UP-REGULATION, MANAGEMENT, MODULATOR, MORTALITY, PROTEIN, INJURY, RISK
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Objective: Acute pancreatitis can cause local or systemic complications and has high morbidity and mortality rates. In the early stages of pancreatitis, a decrease in the barrier function of the intestines and an increase in bacterial translocation are observed. Zonulin is a marker used to evaluate the integrity of the intestinal mucosal barrier. We aimed to investigate whether measuring serum zonulin levels would contribute to the early prediction of complications and severity in acute pancreatitis.