Association between the methylene tetrahydrofolate reductase gene C677T mutation and colchicine unresponsiveness in Behcet's disease

KARAKUŞ N., YİĞİT S., Kalkan G., RÜSTEMOĞLU A., Inanir A., Gul U., ...Daha Fazla

MOLECULAR VISION, cilt.18, sa.174, ss.1696-1700, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 174
  • Basım Tarihi: 2012
  • Dergi Adı: MOLECULAR VISION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1696-1700
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

Purpose: Behcet's disease (BD) is a multisystemic immunoinflammatory disorder characterized by mucocutaneous, ocular, vascular, and central nervous system manifestations. The common methylene tetrahydrofolate reductase (MTHFR) gene C677T mutation is a known risk factor for thrombosis. The aim of this study was to investigate the MTHFR gene C677 mutation in patients with BD and evaluate if there was an association with clinical features, especially thrombosis, in a relatively large cohort of patients with BD.