High association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with recurrent aphthous stomatitis

Karakus N., YİĞİT S., Kalkan G., Sezer S.

Archives of Dermatological Research, vol.305, no.6, pp.513-517, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 305 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.1007/s00403-013-1333-x
  • Journal Name: Archives of Dermatological Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.513-517
  • Keywords: Angiotensin-converting enzyme (ACE), Genetic susceptibility, Insertion/deletion polymorphism, Recurrent aphthous stomatitis (RAS)
  • Ondokuz Mayıs University Affiliated: No


Recurrent aphthous stomatitis (RAS) is a common ulcerative disease of the oral mucosa. Oral ulcers are also the most common feature of Behçet's disease (BD). Association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with BD has been reported in Turkish population. The aim of the present study was to investigate the possible association between ACE gene I/D polymorphism and RAS, and evaluate if there was an association with clinical features in a relatively large cohort of Turkish patients. The study included 198 patients affected by RAS and 214 healthy controls. ACE gene I/D polymorphism genotypes were determined using polymerase chain reaction with I and D allele-specific primers. The genotype and allele frequencies of I/D polymorphism showed statistically significant differences between RAS patients and controls (p < 0.0001 and p < 0.0001, respectively). After stratifying RAS patients according to clinical and demographical characteristics, no significant association was observed. In conclusion, the results of this study suggest that I/D polymorphism of the ACE gene was positively associated with predisposition to develop RAS in Turkish population. Further studies with larger populations are recommended. © 2013 Springer-Verlag Berlin Heidelberg.