This study was carried out to investigate the risk factors relating Highly Pathogen Avian Influenza H5N1 and to evaluate consumer demand and related economic losses for poultry raised in the Kizilirmak Delta. Data were obtained from 361 householders in the Kizilirmak Delta and surrounding rural areas of the delta where a Highly Pathogen Avian Influenza outbreak occurred in 2008. The total cost of the disease outbreak in the area was estimated as 501.768 TL for the 3.116 enterprises. Based on market prices for 2011, the compensation cost for the disease was estimated at 276 TL per enterprise. The time of the Highly Pathogen Avian Influenza outbreaks had happenned, correlation between the consumption of eggs and poultry families were significant at 0.05 level. In conclusion, the present study contributed to the determination of production losses due to the disease Highly Pathogen Avian Influenza, disease-related control and protection measures, estimated payments and direct economic effects.