CIITA expression is regulated by histone deacetylase enzymes and has a role in alpha-synuclein pre-formed fibril-induced antigen presentation in murine microglial cell line

Creative Commons License

Gunaydin C., Celik Z. B., Bilge S. S.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, vol.44, no.3, pp.447-455, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.1080/08923973.2022.2054427
  • Journal Name: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.447-455
  • Keywords: alpha-synuclein, histone deacetylation, microglia, antigen presentation, II TRANSACTIVATOR CIITA, MPTP MOUSE MODEL, PARKINSONS-DISEASE, ACTIVATION, ACETYLATION, NEURODEGENERATION, PATHOGENESIS, LYMPHOCYTES, IMMUNITY
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Aim: Parkinson's disease (PD) is a chronic neurodegenerative disorder related with several genetic and epigenetic factors. In the context of epigenetic factors, histone acetylation is one of the most associated mechanisms with Parkinson's disease progression. This study investigates the effects of the increased histone acetylation on antigen presentation in microglial cells which were induced by preformed fibrils of alpha-synuclein (pFF alpha-synuclein).