CIITA expression is regulated by histone deacetylase enzymes and has a role in alpha-synuclein pre-formed fibril-induced antigen presentation in murine microglial cell line

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Gunaydin C., Celik Z. B., Bilge S. S.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, cilt.44, sa.3, ss.447-455, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/08923973.2022.2054427
  • Dergi Adı: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.447-455
  • Anahtar Kelimeler: alpha-synuclein, histone deacetylation, microglia, antigen presentation, II TRANSACTIVATOR CIITA, MPTP MOUSE MODEL, PARKINSONS-DISEASE, ACTIVATION, ACETYLATION, NEURODEGENERATION, PATHOGENESIS, LYMPHOCYTES, IMMUNITY
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Aim: Parkinson's disease (PD) is a chronic neurodegenerative disorder related with several genetic and epigenetic factors. In the context of epigenetic factors, histone acetylation is one of the most associated mechanisms with Parkinson's disease progression. This study investigates the effects of the increased histone acetylation on antigen presentation in microglial cells which were induced by preformed fibrils of alpha-synuclein (pFF alpha-synuclein).