Epigenetics of nonobstructive azoospermia

Gunes S., Metin Mahmutoglu A., Hekim N.

ASIAN JOURNAL OF ANDROLOGY, vol.27, no.3, pp.311-321, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 27 Issue: 3
  • Publication Date: 2025
  • Doi Number: 10.4103/aja202463
  • Journal Name: ASIAN JOURNAL OF ANDROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Gender Studies Database, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.311-321
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Nonobstructive azoospermia (NOA) is a severe and heterogeneous form of male factor infertility caused by dysfunction of spermatogenesis. Although various factors are well defined in the disruption of spermatogenesis, not all aspects due to the heterogeneity of the disorder have been determined yet. In this review, we focus on the recent findings and summarize the current data on epigenetic mechanisms such as DNA methylation and different metabolites produced during methylation and demethylation and various types of small noncoding RNAs involved in the pathogenesis of different groups of NOA.