Insulin-like growth factor I (Igf-1) gene polymorphism in patients with non-metastatic breast cancer

Yaren A., Turgut S., Ayada C., AKCILAR R., Degirmencioglu S., Gokoz Dogu G.

Gene, cilt.503, sa.2, ss.244-247, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 503 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.gene.2012.04.078
  • Dergi Adı: Gene
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.244-247
  • Anahtar Kelimeler: Breast cancer, Gene polymorphism, Insulin-like growth factor, Prognosis
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

We aimed to assess the association between IGF-I gene (CA repeats) polymorphism in breast cancer patients and their clinicopathological features, as well as disease recurrence and survival. Seventy-six non-metastatic breast cancer patients were enrolled in the present study. The IGF-I (CA) repeats were studied with polymerase chain reaction by using proper primers belonging to these gene areas from DNA samples. Results show that the non 19- non 19 homozygote were more common in patients without lymph node involvement (p = 0.04), with low histological grade (p = 0.04), with positive hormone receptor status (p = 0.01), and in patients without recurrence (p = 0.06). These results suggest that the non 19-non 19 carriers have some favorable prognostic factors, and IGF-I gene polymorphism (CA repeats) may affect disease recurrence and overall survival. © 2012 Elsevier B.V.