Insulin-like growth factor I (Igf-1) gene polymorphism in patients with non-metastatic breast cancer

Yaren A., Turgut S., Ayada C., AKCILAR R., Degirmencioglu S., Gokoz Dogu G.

Gene, vol.503, no.2, pp.244-247, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 503 Issue: 2
  • Publication Date: 2012
  • Doi Number: 10.1016/j.gene.2012.04.078
  • Journal Name: Gene
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.244-247
  • Keywords: Breast cancer, Gene polymorphism, Insulin-like growth factor, Prognosis
  • Ondokuz Mayıs University Affiliated: No

Abstract

We aimed to assess the association between IGF-I gene (CA repeats) polymorphism in breast cancer patients and their clinicopathological features, as well as disease recurrence and survival. Seventy-six non-metastatic breast cancer patients were enrolled in the present study. The IGF-I (CA) repeats were studied with polymerase chain reaction by using proper primers belonging to these gene areas from DNA samples. Results show that the non 19- non 19 homozygote were more common in patients without lymph node involvement (p = 0.04), with low histological grade (p = 0.04), with positive hormone receptor status (p = 0.01), and in patients without recurrence (p = 0.06). These results suggest that the non 19-non 19 carriers have some favorable prognostic factors, and IGF-I gene polymorphism (CA repeats) may affect disease recurrence and overall survival. © 2012 Elsevier B.V.