Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives

GÜNEY M., ÇAVDAR H., ŞENTÜRK M., EKİNCİ D.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.25, no.16, pp.3261-3263, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 16
  • Publication Date: 2015
  • Doi Number: 10.1016/j.bmcl.2015.05.073
  • Journal Name: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3261-3263
  • Keywords: Carbonic anhydrase, Hydroxyl, Uracil, Enzyme inhibitor, ISOFORMS I, ISOENZYMES, ISOZYMES
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Carbonic anhydrase (CA) inhibitors are valuable molecules based on several therapeutic applications, including antiglaucoma activity. In the present study, inhibition of two human cytosolic carbonic anhydrase isozymes I and II with some uracil derivatives (3-9) were investigated. Compounds 3-9 showed K-I values in the range of 10.83-464 mu M for hCA I and of 28.88-778.5 mu M against hCA II, respectively. Kinetic investigations showed that similarly to classical CA inhibitors, all investigated natural compounds act as competitive inhibitors with 4-NPA as substrate. Uracil derivatives investigated here are promising agents which may be used as lead molecules in order to derivative novel carbonic anhydrase inhibitors that might be useful in medical applications. (C) 2015 Elsevier Ltd. All rights reserved.