Lack of Prognostic Significance of SOCS-1 Expression in Colorectal Adenocarcinomas
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, cilt.15, sa.19, ss.8469-8474, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 19
- Basım Tarihi: 2014
- Doi Numarası: 10.7314/apjcp.2014.15.19.8469
- Dergi Adı: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.8469-8474
- Anahtar Kelimeler: Colorectal carcinoma, methylation, suppressor of cytokine signaling-1, tumour suppressor, COLON-CANCER, ABERRANT METHYLATION, JAK/STAT INHIBITOR, HYPERMETHYLATION, SUPPRESSOR, GENE, INACTIVATION, ACTIVATION, CARCINOMA, MUTATION
- Ondokuz Mayıs Üniversitesi Adresli: Evet
Özet
Introduction: Recent studies have indicated that down-regulation of the suppressor of cytokine signaling-1 (SOCS-1) gene results in tumor formation and that SOCS-1 acts as a tumor suppressor gene. SOCS-1 has been also suggested to function as a tumor suppressor with colorectal cancer. Objectives: In the present study, we aimed to determine the association of SOCS-1 expression in colorectal cancer tissues with clinicopathologic characteristics immunohistochemically and also to identify its prognostic significance. Materials and Methods: SOCS-1 expression was studied immunohistochemically in 67 patients diagnosed with resected colorectal carcinomas and 30 control subjects. Results: SOCS-1 expression was found in 46.3% of tumor tissues and 46.7% of the control group. Statistical analyses did not establish any significant association between SOCS-1 expression and clinicopathologic characteristics. Also, no significant association with SOCS-1 expression was found using progression-free survival and overall survival analyses (p=0.326 and p=0.360, respectively). Conclusions: Our results show that SOCS-1 has no prognostic significance in colorectal cancer.