Polyacanthoside A, a new oleanane-type triterpenoid saponin with cytotoxic effects from the leaves of Acacia polyacantha (Fabaceae)

Fotso G., Na-Iya J., Mbaveng A., Ango Yves P., Demirtas I., Kuete V., ...Daha Fazla

Natural Product Research, cilt.33, sa.24, ss.3521-3526, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 24
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/14786419.2018.1486312
  • Dergi Adı: Natural Product Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3521-3526
  • Anahtar Kelimeler: 3-O-methyl-D-Chiro-inositol, Acacia polyacantha, cytotoxicity, drug resistant phenotypes, Fabaceae, leukemia cells, polyacanthoside A
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

The chemical investigation of the leaves and stem bark of Acacia polyacantha (Fabaceae) led to the isolation of a new oleanane-type triterpenoid saponin named polyacanthoside A 1 together with fifteen known compounds. Their structures were established from spectral, mainly HRESIMS, 1D NMR and 2D NMR and by comparison with literature data. The cytotoxicity of compound 1 and the analogues 8 as well as doxorubicin was determined in a panel of 9 cancer cell lines including sensitive and drug resistant phenotypes. Unlike the analogue 8, compound 1 as well as doxorubicin displayed cytotoxic effects in all the 9 tested cancer cell lines with IC50 values ranged from 8.90 μM (towards CCRF-CEM leukemia cells) to 35.21 μM (towards HepG2 hepatocarcinoma cells) for compound 1 and from 0.02 μM (towards CCRF-CEM leukemia cells) to 66.83 μM (against CEM/ADR5000 leukemia cells) for doxorubicin.