C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma
TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY, no.2, pp.163-166, 2020 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Article
- Publication Date: 2020
- Doi Number: 10.5505/tjo.2019.2092
- Journal Name: TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
- Page Numbers: pp.163-166
- Keywords: Deletion, Oral squamous cell carcinoma, P53, PCR
- Ondokuz Mayıs University Affiliated: Yes
Abstract
OBJECTIVE Oral squamous cell carcinoma (OSCC) is the most frequently seen oral malignancy and accounts for up to 80-90% of all malignant neoplasms that occurin the oral cavity. The p53 tumor suppressor gene plays a crucial role in the regulation of the cell cycle. Mutations of the p53 gene havean important role in OSCC carcinogenesis. In this study, we aimed to evaluate the C-deletion mutation in exon 4 codon 63 of p53 gene in Turkish patients with OSCC. METHODS A total of 60 subjects were enrolled in this study, 30 patients with a pathologic diagnosis of OSCC and 30 cases of age and sex-matched healthy controls. Genotyping was performed for all individuals using polymerase chain reaction (PCR) analysis. RESULTS The findings showed that the distribution of p53 exon 4 codon 63 C-deletion was significantly different between patient group and control group (p=0.000). It was detected that all patients had C-deletion mutation in exon 4 codon 63 of p53. CONCLUSION Our results suggest that C-deletion in exon 4 codon 63 deletion of the p53 gene may play a role in the pathogenesis of human OSCC in a Turkish cohort.