Disseminated fungal infection by Aureobasidium pullulans in a renal transplant recipient
PEDIATRIC TRANSPLANTATION, vol.22, no.3, 2018 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 22 Issue: 3
- Publication Date: 2018
- Doi Number: 10.1111/petr.13152
- Journal Name: PEDIATRIC TRANSPLANTATION
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Keywords: Aureobasidium pullulans, fungal infection, pediatrics, renal transplant, vacuum-assisted closure therapy, VACUUM-ASSISTED CLOSURE, SUBCUTANEOUS MYCOSIS, WOUND MANAGEMENT, VAR.-MELANIGENUM, FUNGEMIA, PHEOHYPHOMYCOSIS
- Ondokuz Mayıs University Affiliated: Yes
Abstract
Renal transplant recipients are on long-term potent immunosuppressive therapy, which makes them highly vulnerable to opportunistic fungal infections. Dematiaceous, or dark-pigmented saprophytic fungi, are being increasingly seen as opportunistic pathogens of mycoses in immunosuppressed patients. One of these is Aureobasidium pullulans, which is a black yeast-like dematiaceous fungus found ubiquitously in the environment that can cause various opportunistic human infections. Most infections occur by traumatic inoculation, such as keratitis and cutaneous lesions; disseminated mycoses are very rare and occur only in severely immunocompromised patients. We report a case of disseminated fungal infection due to A.pullulans in a pediatric patient who underwent renal transplant. The use of voriconazole and vacuum-assisted closure along with surgical drainage most likely contributed to the patient's positive outcome.