Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity

Kayacan, Yıldırım; Ghojebeigloo, Babak; Cerit, Gunay; Kocacan, Süleyman; Ayyıldız, Mustafa

doi:10.1016/j.yebeh.2020.107403

Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity

Kayacan Y., Ghojebeigloo B. E., Cerit G., Kocacan S. E., Ayyıldız M.

EPILEPSY & BEHAVIOR, vol.112, 2020 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 112
Publication Date: 2020
Doi Number: 10.1016/j.yebeh.2020.107403
Journal Name: EPILEPSY & BEHAVIOR
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE, Psycinfo
Keywords: 5-Hydroxyuyptophan, Exercise, Epilepsy, Spike, Epileptiform activity, EPILEPSY, TRYPTOPHAN, NOREPINEPHRINE, BRAIN
Ondokuz Mayıs University Affiliated: Yes

Abstract

Aim: Previous studies have shown that 5- hydroxytryptophan (5-HTP) and exercise play an important role in the synthesis of serotonin independently. The effects of the treadmill exercise and 5- hydroxytryptophan (5-HIP) on seizure mechanisms created by epileptiforrn activity with penicillin model were investigated in rats.