Investigating dose finding methods and different priors in Bayesian continual reassessment method

Koc T., Cengiz M. A.

KUWAIT JOURNAL OF SCIENCE, cilt.47, sa.1, ss.22-32, 2020 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 1
  • Basım Tarihi: 2020
  • Dergi Adı: KUWAIT JOURNAL OF SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Arab World Research Source, zbMATH
  • Sayfa Sayıları: ss.22-32
  • Anahtar Kelimeler: Bayesian inference, clinical trial, maximum tolerated dose, prior selection, CLINICAL-TRIALS, DESIGN, ESCALATION
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

A well-designed and properly analyzed clinical trial is a powerful tool for the development of new drugs. Clinical trials are studies that explore whether a treatment, drug or device is safe and effective for humans. These studies can show which drug development method works best for certain diseases. The first step in drug discovery (phase I) is very important to determine maximum tolerated dose (MTD).