EXPRESSION OF iNOS, COX-2 AND VEGF IN CANINE MAMMARY TUMOURS AND NON-NEOPLASTIC MAMMARY GLANDS: ASSOCIATION WITH CLINICOPATHOLOGICAL FEATURES AND TUMOUR GRADE

Creative Commons License

ANADOL E., YAR SAĞLAM A. S., Gültiken N., Karakas K., Alcigir E., ALKAN H., ...More

ACTA VETERINARIA HUNGARICA, vol.65, no.3, pp.382-393, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.1556/004.2017.036
  • Journal Name: ACTA VETERINARIA HUNGARICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.382-393
  • Keywords: Canine mammary tumour, gene expression, iNOS, COX-2, VEGF, OXIDE SYNTHASE EXPRESSION, HUMAN BREAST-CANCER, NITRIC-OXIDE, CYCLOOXYGENASE-2 EXPRESSION, PROGNOSTIC-SIGNIFICANCE, GROWTH-FACTOR, CARCINOMA, ANGIOGENESIS, DOGS, SURVIVAL
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

The aim of the present study was to investigate the relationship between the expression of iNOS, COX-2 and VEGF mRNA levels and malignancy degree in canine malignant mammary tumours. Thirty-five bitches presented with the complaint of mammary masses, aged 6-10 years and representing different breeds, were used. The expressions of iNOS, COX-2 and VEGF mRNA levels were significantly higher in both benign and malignant tumours than in the adjacent nonneoplastic mammary glands (P < 0.05). The iNOS, COX-2 and VEGF mRNA expression levels of grade 2 tumours were higher than those of grade 1 tumours; however, the highest expression levels were detected in grade 3 tumours. Thus, increased iNOS, COX-2 and VEGF gene mRNA levels were found to be related with the histological grade of malignancy in dogs with mammary tumours.