DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY, vol.29, no.5, pp.647-655, 2023 (SCI-Expanded)
PURPOSE The present study aims to evaluate whether perfusion parameters in prostate magnetic resonance imaging (MRI), Ga-(68)-prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT), prostate-specific antigen (PSA), and PSA density can be used to predict the lesion grade in patients with prostate cancer (PCa). METHODS The study included a total of 137 PCa cases in which 12-quadrant transrectal ultrasound-guided prostate biopsy ( TRUSBx) was performed, the Gleason score (GS) was determined, and pre-biopsy multiparametric prostate MRI and Ga-(68)-PSMA PET/CT examinations were undertaken. The patient population was evaluated in three groups according to the GS: (1) low risk; (2) intermediate risk; (3) high risk. The PSA, PSA density, pre-TRUSBx Ga-(68)-PSMA PET/CT maximum standardized uptake value (SUVmax), perfusion MRI parameters [maximum enhancement, maximum relative enhancement, T0 (s), time to peak (s), wash-in rate (s(-1)), and wash-out rate (s(-1))] were retrospectively evaluated. RESULTS There was no significant difference between the three groups in relation to the PSA, PSA density, and Ga-(68)-PSMA PET/CT SUVmax (P > 0.05). However, the values of maximum enhancement, maximum relative enhancement (%), T0 (s), time to peak (s), wash-in rate (s(-1)), and wash-out rate (s(-1)) significantly differed among the groups. A moderate positive correlation was found among the prostate volume, PSA (r = 0.490), and Ga-(68)-PSMA SUVmax (r = 0.322) in the patients. The wash-out rate (s(-1)) and wash-in rate (s(-1)) had the best diagnostic test performance (area under the curve: 89.1% and 78.4%, respectively). CONCLUSION No significant correlation was found between the Ga-(68)-PSMA PET/CT SUVmax and the GS. The washout rate was more successful in estimating the pretreatment GS than the Ga-(68)-PSMA PET/CT SUVmax