Diazenyl-hydrazone functionalized silatrane hybrids: Integrating structural precision for Al (III) sensing and anticancer activity

Singh G., Heena H., Meral S., Markan P., Kaur H., Gill B. S., ...More

JOURNAL OF MOLECULAR STRUCTURE, vol.1352, 2026 (SCI-Expanded, Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 1352
  • Publication Date: 2026
  • Doi Number: 10.1016/j.molstruc.2025.144486
  • Journal Name: JOURNAL OF MOLECULAR STRUCTURE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

This manuscript investigates the synthesis and potential of a silatrane-tethered hydrazone derivative as a multifunctional compound capable of selective metal ion sensing, anticancer activity. The synthesized compound demonstrated high sensitivity and selectivity for Al(III) through UV-Vis and fluorescence spectroscopy with 18.73 and 3.46 nM LOD values, respectively, highlighting its effectiveness as a chemosensor. Additionally, both in-vitro and in-silico studies confirmed its promising anticancer properties. The integration of the silatrane framework with the hydrazone moiety enhanced the stability and optical properties of the compound, positioning it as a versatile candidate for addressing key challenges in environmental monitoring and therapeutic interventions. The results indicate that the silatrane-tethered hydrazone holds significant promise for applications in metal ion detection, cancer treatment, providing a foundation for further exploration and development of multifunctional systems with dual sensing and therapeutic roles.