The Role of Interleukin-4 VNTR Polymorphism in Dysmenorrhea Development

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ESEN M., NURSAL A. F., Duman E., YİĞİT S.

HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI, vol.58, no.4, pp.364-369, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.4274/haseki.galenos.2020.6162
  • Journal Name: HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.364-369
  • Keywords: Dysmenorrhea, interleukin-4, VNTR, PCR, GENE POLYMORPHISMS, ASSOCIATION, PAIN, VASOPRESSIN, PREVALENCE, VARIANTS, SEVERITY, SAMPLE, PLASMA
  • Ondokuz Mayıs University Affiliated: Yes

Abstract

Aim: Primary dysmenorrhea (PD) is among the most common gynecological diseases in young women presenting to emergency department. It has been shown that cytokines played roles in PD pathogenesis. Interleukin-4 (IL-4), a cytokine, regulates multiple biological functions. The objective of the present study was to examine possible relationship between IL-4 variable number of tandem repeat (VNTR) polymorphism and susceptibility to PD.